Conference Program

If you did not have a chance to attend the 4th Annual ISNVD conference you can still obtain access to the presentations for a fee of $75. Once purchased, the presentation will be available for download in PDF format. Please note that 9 out of the 50 sessions and abstracts are not available for download.

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6:00 p.m.

Keynote Presentation - The Role of Blood Vessels and Inflammation in the Pathogenesis of Neurological Disorders

Dr. Paula Grammas

7:00 p.m.

Welcome Reception




8:00 – 8:10 a.m.

Welcome and Introduction


Session 1: A Multi-Modality Approach to Extra Cranial Venous Disease

Session Chairpersons: Dr. Robert Zivadinov 

8:10 – 8:22 a.m.

The Current Status of Ultrasound Imaging for the Screening of CCSVI

Dr. Marcello Mancini

8:22 – 8:34 a.m.

What is the Normal Jugular Vein Valve Function?

Dr. Erica Menegatti

8:34 – 8:46 a.m.

Prevalence of Extracranial Venous Narrowing on Catheter Venography in People with Multiple Sclerosis: Results of a Blind Study. 

Dr. Lindsay Machan

8:46 – 8:58 a.m.

Identifying CCSVI with Cervical Plethysmography

Dr. Paolo Zamboni

8:58 – 9:10 a.m.

Diagnostic Contributions of Catheter Venography for Screening of CCSVI

Dr. Hector Ferral

9:10 – 9:22 a.m.

What Additional Information Can Intravascular Ultrasound Provide?

Dr. Adnan Siddiqui

9:22 – 9:34 a.m.

Molecular Markers of Abnormal CNS Hemodynamics

Dr. Steven Alexander

9:34 – 9:46 a.m.

State of the Art I: Why We Need a Multi-Modality Diagnostic Approach for CCSVI

Dr. Robert Zivadinov

9:46 – 10:00 a.m.



10:00 – 10:10 a.m.

Submitted Abstract 1 - Extracranial brain draining veins in a mouse: Assessment by High Resolution Ultrasound and MR Angiography of the neck 

Marcello Mancini, M.D., Giuseppe Palma, Ph.D., Enrico Tedeschi, M.D., Adelaide Greco, Ph.D. , Monica Ragucci 

10:10 – 10:20 a.m.

Submitted Abstract 2- Inverse Relationship between Internal Jugular Vein Narrowing and Increased Brain Volumes in Healthy Individuals

Chris Magnano, M.S., Pavel Belov, Jacqueline Krawiecki, Steven Grisafi, Jesper Hagemeier, M.S., Clive, B. Beggs, Ph.D., Robert Zivadinov M.D., Ph.D. 

10:20 – 10:40 a.m.

Refreshment Break – Technical Exhibits


Session 2: The Treatment of Abnormal Venous Flow

Session Chairperson: Dr. Ziv Haskal

10:40 – 10:56 a.m.

Designing an Endovascular Trial – What Elements are Essential and Why CCSVI Trials Might Differ from Disease Modifying Trials?

Dr. Kottil W. Rammohan

10:56 – 11:10 a.m.

State of the Art II: Current Results of Safety and Efficacy of CCSVI Therapy in MS Patients

Dr. Gary Siskin

11:10 – 11:26 a.m.

Procedural Endpoints: How to Best Measure Meaningful Flow Impairment, Inter- and Post-Procedural Therapy


A - IVUS Driven Intervention

Dr. Hector Ferral


B. Optimizing Pure Venographic Therapy

Dr. Hector Ferral

11:26 – 11:42 a.m.

Intervention Studies in 2014:


A. The Time is Ripe for Primary and Replicative Therapy Trials in MS

Dr. Ziv Haskal


B. Therapy Trials Need to Wait. The Landscape has Changed

Dr. Kottil W. Rammohan

11:42 – 11:55 a.m.



11:55 – 12:05 a.m.

Submitted Abstract 3 - A Report of Four Cases of Anterior Cranial Fossa (Ethmoidal Type) Dural Arteriovenous Fistula: Surgical Considerations andTechnique Using Intraoperative Indocyamine Green Angiography. 

Kuhyun Yang, M.D., Jae Sung Ahn, M.D., Ph.D., Jung Cheol Park, M.D., Do Hoon Kwon, M.D., Byung Duk Kwun, M.D., Ph.D.

12:05 – 12:15 p.m.

Submitted Abstract 4 - Classification of Venous Outflow in the Extracranial Vessels in a Large Cohort of MS Patients 

Sean Sethi, MS, David Utriainen, Robert Loman, MD, Imran Saqib, E. Mark Haacke, Ph.D.

12:15 – 1:00 p.m.

ISNVD Business Meeting and Lunch


Session 3: Potential Role of Extracranial Venous System in CNS Disorders and Aging 

Session Chairperson: Dr. Chih-Ping Chung

1:00 – 1:12 p.m.

CCSVI and Parkinsons Disease

Dr. E. Mark Haacke

1:12 –1:24 p.m.

Etiologies of Jugular Venous Abnormalities in Transient Monocular Blindness

Dr. Chun-Yu Cheng

1:24 – 1:36 p.m.

Age-Related White Matter Changes, Alzheimer’s Disease and Jugular Venous Reflux.

Dr. Clive Beggs

1:36 – 1:48 p.m.

Cerebral Venous Drainage Impairment in Idiopathic Intracranial Hypertension

Dr. Noam Alperin

1:48 – 2:00 p.m.

Headache and Venous Abnormalities

Dr. Wei-Ta Chen

2:00 – 2:12 p.m.

Venus Abnormalities Involved in High Altitude-Associated Neurological Disorders

Mr. Mark Wilson

2:12 – 2:24 p.m.

Cerebral Venous Drainage Impairment And Cerebral Small Vessel Disorders

Dr. Han-Hwa Hu

2:24 – 2:36 p.m.

The Role of Inflammation Factors in Chronic Cereral Venous Insufficiency: From The View of Lower Limbs’ Venous Disorders.

Dr. Chris Imray

2:36 – 2:50 p.m.

The Future Perspective of Researches on Neurological Diseases Associated with Chronic Cerebral Venous Insufficiency.

Dr. Chih-Ping Chung

2:50 – 3:00 p.m.



3:00 – 3:10 p.m.

Submitted Abstract 5 - The Nature of Abnormal Ultrasongraphic findings in Internal Jugular Veins

Chun-Yu Cheng, M.D., Han-Hwa Hu, M.D., Chih-Ping Chung, M.D. 

3:10 – 3:20 p.m.

Submitted Abstract 6 - CCSVI is Associated with Subcortical Deep Gray Matter Abnormalities in Healthy Individuals. A Diffusion Tensor MRI Study

Roberto Cappellani, Niels Bergsland, Jesper Hagemeier,  Karen Marr, Cheryl Kennedy, Ellen Carl, Deepa P. Ramasamy, Michael G. Dwyer, Bianca Weinstock-Guttman, Robert Zivadinov

3:20 – 3:30 p.m.

Refreshment Break – Technical Exhibits


Session 4: Quantifying Flow in Neurological Diseases

Session Chairperson: Dr. Michael Dake

3:30 - 3:42 p.m.

Normal Regulatory Mechanisms of CNS Blood Flow

Dr. Eric C. Peterson

3:42 – 3:54 p.m.

Understanding the Blood-Brain Barrier in Health and Disease

Dr. Steven Alexander

3:54 – 4:06 p.m.

Origin of Craniospinal CSF Flow Pulsation and How We Measure It

Dr. Noam Alperin

4:06 – 4:18 p.m.

The Lymphatic System: What is its Normal Role and What Can Go Wrong?

Dr. Roy O. Weller

4:18 – 4:30 p.m.

The Use of Biomarkers to Evaluate Glymphatic System Function

Dr. Leonard Prouty


4:30 – 4:42 p.m.

Venous Hemodynamics in Neurologic Disorders

Dr. Clive Beggs

4:42 – 4:54 p.m.

Theoretical Study of Cerebral Venous Haemodynamics Associated with the CCSVI Condition

Dr. Eleuterio Toro

4:54 – 5:10 p.m.



5:10 – 5:20 p.m.

Submitted Abstract 7 - Observed differences of PC-MRI measured venous outflow and CSF pulsatility in migraine subjects receiving Atlas Correction Intervention 

H. Charles Woodfield, BS Pharmacy, DC1, Clive Beggs, PhD, D. Gordon Hasick, DC3

5:20 – 5:30 p.m.

Submitted Abstract 8 - Relationship between Jugular Venous Reflux and Perihematoma Edema and Outcome after Spontaneous Itracerebral Hemorrhage 

Hao Feng, Xingquan Zhao, Hongxia Zhang†, Ye Cheng†, Liping Liu
 5:30 p.m.





8:00 – 8:05 a.m.

Introduction and Announcements


Session 5: Monitoring Hemodynamics of the Brain

Session Chairperson: Dr. E. Mark Haacke

8:05 – 8:25 a.m.

Nitric Oxide and a Vascular Hypothesis in Multiple Sclerosis

Dr. Yulin Ge

8:25 – 8:45 a.m.

Perfusion Imaging in Stroke: Its’ Current Clinical Status and its Role in Treating Patients

Dr. Larry Latour

8:45 – 9:05 a.m.

Hemodynamic Impairment in Multiple Sclerosis: Imaging Techniques and Perspectives

Dr. Yulin Ge

9:05 – 9:20 a.m.

SPECT and PECT Perfusion Changes After CCSVI Restoration

Dr. Paolo Zamboni

9:20 – 9:30 a.m.



9:30 – 9:40 a.m.

Submitted Abstract 9 - Cerebral Hemodynamic Changes in Mild Traumatic Brain Injury at the Acute Stage 

Hardik Doshi, Wentao Wang,  Robert Welch, Brian O’Neil, Grace Ma, Randall Benson, E Mark Haacke and Zhifeng Kou

9:40 – 9:50 a.m.

Submitted Abstract 10 - Altered IJV hemodynamics and impaired cerebral autoregulation in patients with panic disorder

Yu -Chien Tsao, Chun-Yu Cheng, I-Hui Wu, Chih-Ping Chung, Han-Hwa Hu

9:50 – 10:10 a.m.

Refreshment Break – Technical Exhibits


Session 6: Traumatic Brain Injury (TBI) and Vascular Consequences

Session Chairperson: Dr. E. Mark Haacke

10:10 –10:35 a.m.

State of the Art IV: Understanding the Fundamental Physiology of TBI: From Research To Treatment

Dr. Ramon Diaz-Arrastia

10:35 –10:50 a.m.

Typical Vascular Lesions of TBI and Their Evolution

Dr. Gunjan Parikh

10:50 – 11:10 a.m.

The Clinical Spectrum and Natural History Of TBI Sequelae

Dr. Karen Tong

11:10 –11:25 a.m.

State of the Art IV: The Role of Imaging and Venous Abnormalities in TBI

Dr. Zhifeng Kou

11:25 –11:35 a.m.

Submitted Abstract 11 - Hemorrhagic lesions based on venous and arterial damage and its clinical correlation in Traumatic Brain Injury 

Hardik Doshi, JunLiud, Robin Hanks, E Mark Haacke, Zhifeng Kou

11:35 – 11:45 a.m.

Submitted Abstract 12 - Thalamic Shape and Cognitive Performance in Amnestic Mild Cognitive Impairment 

Hyun-Kook Lim, Seung-Chul Hong 

11:45 a.m. – noon